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KMID : 0359320090490010059
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Korean Journal of Veterinary Research
2009 Volume.49 No. 1 p.59 ~ p.62
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Single-nucleotide polymorphisms in prion protein gene of the Korean subspecies of Chinese water deer (Hydropotes inermis argyropus)
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Choi In-Soo
Jeong Byung-Hoon
Jeong Hyun-Jeong
Kim Bo-Sook
Kim Yong-Sun
Lee Joong-Bok
Park Seung-Yong
Rho Jung-Rae
Song Chang-Seon
Yoo Mi-Hyun
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Abstract
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Susceptibility to chronic wasting disease (CWD) in cervid species has been associated with polymorphisms in the prion protein gene (PRNP). The single nucleotide polymorphisms (SNPs) were found in the PRNP of the Korean subspecies of Chinese water deer via analyses of the DNA sequences obtained from 34 individual deer. Two SNPs were detected at codons 77 and 100. One SNP at codon 77 encoding Glycine was determined to be a silent mutation but the other SNP detected at codon 100 induced an amino acid change, from Asparagine to Serine. The prion protein (PrP) amino acid sequence of the water deer showed 98.8-99.2% homology with those of American elk, white-tailed deer and mule deer. The PrP of the water deer contained amino acid residues closely related with CWD-susceptibility. This study is the first to describe genetic variations in the PRNP of the Korean subspecies of Chinese water deer.
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KEYWORD
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CWD, PRNP, SNP, susceptibility, water deer
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